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For the Zepbound OSA indication, Tricare references SURMOUNT-OSA, which showed AHI reduction of 27-30 events per hour over 52 weeks in patients with moderate-to-severe OSA and obesity

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Molecular pathways documented in preclinical research include: (1) activation of nitric oxide (NO) synthesis via L-arginine/eNOS pathway, (2) transcriptional upregulation of VEGF-A and FGF-2 favouring angiogenesis, (3) modulation of the Egr-1 early transcription factor involved in fibroblast proliferation, (4) interaction with 5-HT2A and dopaminergic receptors in some behavioural models, (5) stabilisation of endothelial function via eNOS modulation and reduction of oxidative stress (8-OH-dG, MDA)

You should have reached your desired weight loss goal, are not actively losing weight anymore, have stable blood sugar levels, and your appetite is well controlled

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