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By activating these receptors, tirzepatide: Enhances insulin secretion in a glucose-dependent manner (reducing hypoglycaemia risk) Suppresses glucagon release, lowering hepatic glucose production Slows gastric emptying, promoting satiety Acts on central appetite centres in the hypothalamus to reduce food intake In clinical trials (SURMOUNT programme), tirzepatide produced significant weight loss (typically 1520% of body weight at the highest doses in carefully selected trial populations) alongside improvements in glycaemic control

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Known for its energy-boosting properties, B12 can help increase energy levels, reducing feelings of fatigue

6a and Supplementary Fig