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Another approach to modulate NNMT involves bisubstrate inhibitors, which are designed to resemble both the substrate (NAM) and the cofactor (SAM)

These metabolites accumulate when b12 function becomes inadequate, sometimes before serum b12 drops below normal range

Science 257 , 14961502 (1992)

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(12, 13) Helping to regenerate vitamins C, E and A, all antioxidants or vitamins with antioxidant properties in their own right

Reduced glutathione therefore serves as a functional downstream marker of how well methylation and sulfur metabolism are working together to support detoxification and oxidative balance