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It is known that high doses of APAP are toxic for two reasons

Cancellations or reschedules must be made at least 24 hours in advance or the full amount will be forfeited

Consistency over 8 to 12 weeks is typically more impactful than short-term high dosing

In contrast, abundant evidence demonstrates that enhancing Nrf2 signaling is potently neuroprotective in models of neurodegeneration, although the exact mechanism by which this is achieved is unclear

Animals were randomised in two groups (n = 6) and fed a standard diet (MilRatti Stefano Morini, S