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Pharmacokinetic Profile Route of Administration Oral Half-Life 6-8 hours Route of Administration: Oral, Intravenous Dosing Frequency: Once per day Half-Life: ~6-8 hours Formulation & Handling Soluble in saline

PMID: 31190960

Combining compounds with overlapping metabolic mechanisms (e.g., KLOW + MOTS-c, both targeting mitochondrial function and AMPK) could theoretically amplify effects and side effects in unpredictable ways

The C-terminal residues form a set of inter- and intra-molecular, antiparallel -bridges between hTrxR1 residues 495 hTrxR1 to 499 hTrxR1 and hTrx1 residues 72 hTrx1 to 75 hTrx1 as well as a mixed disulphide between U498C hTrxR1 and Cys32 hTrx1 (Fig

[PMID: 29995655] PubMed record related to this compound for laboratory literature review

Arrow legend: Solid arrows denote positive signal flow/translocation