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Results Dosing of mGIPR-Ab or mGIPR-Ab/GLP-1 produces weight loss To investigate the role of GIPR in energy balance in the CNS, male mice that were fed a high-fat diet (HFD) were administered intracerebroventricular (ICV) injections of varying doses of a fully human anti-human GIPR antibody that cross-reacts with mouse GIPR (mGIPR-Ab)
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The satiety cascade, first proposed in the 1980s and modified throughout, indicates that satiation and satiety are governed by the interplay of metabolic, cognitive, and sensory factors, which are interconnected components [31,33,34]
Cell Metab 34(9):1234-1247.e1239
combined primer annealing and extension for 60 seconds at 60 C
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