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MC1R activation by MT-1 drives cAMP-PKA signalling that upregulates nucleotide excision repair enzymes, reduces cyclobutane pyrimidine dimer formation following UV challenge, activates antioxidant defence pathways, and suppresses UV-induced inflammatory cytokine production through NF-B inhibition
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Conversely, age-related downregulation of antioxidant enzymes (e.g., catalase and SODs) triggers a vicious cycle of impaired H 2 O 2 scavenging, further exacerbating mtROS damage [299, 300]
Moreno, S
Most notably, serums and moisturizers with one key ingredient: growth factors or GF
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