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The doses used in animal studies, when adjusted for body weight, may not correspond to the human dose in the supplement

Skeletal muscle Nucleo-Mitochondrial crosstalk in obesity and type 2 diabetes

As research on the gut microbiome in schizophrenia expands, integrating C4 genotyping with microbiome analysis is of great importance

Although peripheral AC levels may not directly reflect brain-specific alterations, their role in systemic energy balance suggests an impact on central processes like mood regulation [18]

Additionally, certain microbial communities, such as the Prevotella microbiome, appear to be associated with milder depressive symptoms, implying that specific microbiota may offer a protective effect against depression [488]