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In striking contrast, compound 10 did not decrease cholesterol build-up in Rab7-depleted M12 cells, suggesting that its ability to elevate Rab7-GTP levels is the underlying mechanism promoting cholesterol removal in NPC1 mutant cells

The nanocarriers were synthesized as shown in Fig

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An RDP study with 40 patients investigated the effects of 300 mg Pycnogenol supplementation per day for two months on subjects with chronic venous insufficiency (CVI) (32)

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