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While gastrointestinal AEs such as nausea and vomiting dominate safety reports 8 and recent pharmacovigilance studies highlight increasingly recognized risks including acute pancreatitis, nephritis, hypotension, and syncope 9,10,11 , emerging data suggest that GLP-1 RAs may be associated with neurological adverse events (NAEs) 12,13

Genetic factors, metabolic health, medication interactions, and hormonal status all influence outcomes

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Leaders in the field stressed that conducting large, rigorous studies, even the long-shot ones, helps close unproductive avenues, clarify hypotheses, and guide investment toward more promising strategies

Neuroprotection research includes hippocampal ischemia-reperfusion models in rats (PMID 32558293) and investigations into the brain-gut axis as a candidate explanatory framework for the broad effects observed across tissue types (PMID 27138887)

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