Synthetic lethality by targeting glutathione and pyrimidylate kinases in human CML-BC cell lines Finally, we further used several human blast-crisis CML cell lines, including K562, KOPM28, and TCCS, to verify the relationship between ATF4, GSH, and replication stress
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Hypoxia at the injury site resolves faster with improved perfusion, removing the oxygen-deficit barrier to fibroblast metabolism
Finally, designing advanced nanocarriers with improved stability, controlled release, and enhanced tumor penetration will further accelerate the clinical translation of GSH-responsive nanomedicine
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