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Meanwhile, abundant hydrolytic enzymes and microbial flora in the buccal microenvironment constitute biochemical and microbial barriers, triggering drug molecular degradation and inactivation

noted that plasma levels of -MSH (a melanocortin agonist, like -endorphin, also encoded within POMC) varied across different-pigmented mice, paralleling -endorphin levels (i.e., higher -MSH levels in mice with more melanocytes

Eur J Neurol (2018) 25(1):5970