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Dose-escalation protocols used in the Phase 2 trial began at sub-therapeutic doses and escalated over 8-16 weeks, which is believed to minimize gastrointestinal adverse events

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(NIDDK) I also see a second misconception: that success on these medications is purely about eating less. In reality, the reason many patients do better with GLP-1-based treatment is that these medications can change the biology driving overeating, poor fullness signaling, and dysregulated blood sugar

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