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BCAA insufficiency leads to premature ovarian insufficiency via ceramide-induced elevation of ROS

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Incretin mimetics are ideal candidate therapies for T2D as they exert their actions specifically during hyperglycaemic conditions and have the additional capacity to regulate body weight ( Since 2005, six incretin therapy drugs have been approved by the FDA (United States) and the MHRA (United Kingdom) for T2D treatment: Exenatide, Lixisenatide, Liraglutide, Dulaglutide, Semaglutide and Tirzepatide, all of which are administered daily or once weekly via subcutaneous injection

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Preclinical obesity refers to excess adiposity without current organ dysfunction, but with increased future risk