When B12 levels fall below normal ranges, the bone marrow produces abnormally large, immature red blood cells called megaloblasts, which cannot function effectively to transport oxygen throughout the body
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Regarding the analysis populations, the early escalation group included 62 patients in the efficacy set and 63 in the safety set
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The calculated IC 50 was 38 nM with confidence interval [3444 nM] for nitrite secretion, 54 nM [4959 nM] for PGE 2 secretion, and 41 nM [3745 nM] for IL-6 secretion (Fig