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The Phase 2 combination trial in type 2 diabetes reported that, by its 32-week endpoint, the cagrilintide-plus-semaglutide arm reached 15.6% mean weight loss versus 8.1% for cagrilintide alone and 5.1% for semaglutide alone with the combination curve already diverging upward through the early months (Frias et al., 2023)