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Moreover, upon internalization of EV-derived VDAC1 protein by PTX-sensitive GC cells, these cells acquired a PTX-resistant phenotype manifested through AMPK activation and concomitant mTOR signaling pathway inactivation
In addition, a selective GIP agonist showed very low effectiveness in reducing weight, while this co-agonist showed synergism in reducing fat mass in obese rodents
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