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GIP receptor co-activation is believed to potentiate insulin secretion, improve lipid metabolism, and enhance central appetite regulation through mechanisms complementary to GLP-1R signaling

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Animals were housed in micro-isolator cages (maximum 4 animals per cage) in a biosafety 3 controlled environment (22 C, 3070% humidity, 12:12 h photoperiods, 10 air cycles/h), with ad libitum access to food and water

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