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About this article Cite this article Agarwal, A., Sengupta, P

Regardless of pathway, GLP-1 medications require evaluation and monitoring by licensed healthcare providers

MACE-5 (all-cause death, MI, stroke, heart failure event, coronary revascularisation) 44 events on retatrutide, 52 on placebo: In-study: HR 0.82 (95% CI 0.551.22) On-treatment: HR 0.73 (95% CI 0.471.12) MACE-3 (CV death, MI, stroke) 27 events on retatrutide, 23 on placebo: In-study: HR 1.12 (95% CI 0.641.96) On-treatment: HR 0.92 (95% CI 0.511.65) Lilly states plainly that MACE occurred less frequently than anticipated in both arms

Explaining why GLP-1 drugs improve health without weight loss defies simple narratives and confounds researchers

What Did Retatrutides Phase 3 Trials Find

Biallelic variants in TAMM41 are associated with low muscle cardiolipin levels, leading to neonatal mitochondrial disease