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This suggests that direct COP1-p53 recognition may require additional cofactors, adaptors, or specific cellular signal conditions such as glucose induce assembly of CRL4 COP1 for p53 degradation, as suggested in Su et al 29
In rare cases, some people may experience gastroparesis, or delayed gastric emptying, in which the stomach takes longer than usual to empty food
doi:10.2337/db08-1618 111
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