These drugs, widely used for weight loss, mimic a natural hormone in the body to help regulate appetite, slow digestion, and, for some people especially those living with type 2 diabetes lower blood glucose levels
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A FAERS database analysis of suicidal tendencies associated with GLP-1 RAs showed disproportionate reports of suicidal ideation and depression/suicide for semaglutide and liraglutide, but no disproportionate signals for suicidal behavior, attempted suicide, or suicide death across all FDA-approved GLP-1 RAs [Reference McIntyre, Mansur, Rosenblat and Kwan48]
As a result, many healthcare providers now prescribe these drugs as part of a comprehensive treatment plan for obesity, particularly for patients with comorbidities such as type 2 diabetes, heart disease, and hypertension
AUTHOR CONTRIBUTIONS Conception or design: A.B.M.K.H., D.D
