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A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction

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When BPC-157 is used in ex-vivo or cell culture systems, investigators still follow biosafety guidance related to handling human or animal tissues, disposing of biological waste, and documenting any unexpected findings

This method involves anchoring the C-terminal amino acid to a solid support and then sequentially adding the remaining amino acids