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In the CANVAS trial, 10,142 patients with T2DM and a high risk of CVD were randomly assigned to receive canagliflozin or placebo and were followed for a mean duration of 188.2 weeks

1 6 If anything, this makes the retatrutide figure an under -estimate of its eventual ceiling but it equally means we are comparing an unfinished curve to two finished ones, which is another reason the bars are not truly commensurable

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Weight loss inevitably involves some lean mass loss, and resistance training is the most effective countermeasure