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This discovery, reported in Cell Metabolism , challenged the traditional view of mitochondria solely as power generators and introduced the concept of bidirectional mitochondrial-nuclear communication
In PDPN, these mechanisms facilitate ectopic neuronal activity and enhance response to sensory stimuli
It becomes more likely as diabetes lasts longer, glucose control remains poor, and other risk factorssuch as hypertension and kidney diseaseaccumulate
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Plus, with yesterday's news of Cigna capping out of pocket costs for Wegovy and Zepbound to just $200, some truly positive strides are being made towards accessibility
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
