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Neuropathol Appl Neurobiol

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3.2 Peripheral GLP-1 signalling in taste pathways: cellular plausibility and translational limits Preclinical studies indicate that GLP-1 is produced in distinct subpopulations of mammalian taste bud cells (TBCs) ( GLP-1 acts on neighbouring GLP-1R-positive afferent nerve terminals within the taste bud, thereby forming a local regulatory circuit that influences the early encoding of taste signals ( Functional studies suggest that the GLP-1/GLP-1R axis can alter the firing properties of specific gustatory nerve fibres and modulate early afferent taste signalling, particularly in preclinical models ( 3.3 Localisation of endogenous GLP-1 and GLP-1 receptors in the rodent and human brain Endogenous GLP-1 is not exclusively derived from peripheral intestinal L-cells