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However, emerging lawsuits claim the drug caused an eye condition called non-arteritic anterior ischemic optic neuropathy NAION

Yes, metformin is still first-line for many patients, especially those without significant cardiovascular or renal risk

By activating both incretin pathways, tirzepatide enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, delays gastric emptying, and reduces appetite through central nervous system effects

Medication may not be appropriate for everyone

Separate phase III CVOTs of GLP1R agonists are currently being conducted in people living with heart failure with preserved ejection fraction and in those with obesity