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A quantitative metabolomics profiling approach for the noninvasive assessment of liver histology in patients with chronic hepatitis c

Major metabolites found were trimethylamine N-oxide, primarily in urine (8% to 49% of the administered dose) and [3H]--butyrobetaine, primarily in feces (0.44% to 45% of the administered dose)

B.BoltonJ

Following treatment with DC661, the transcriptional levels of three hallmarks of ferroptosisprostaglandin-endoperoxide synthase 2, cationic amino acid transporter 1, and cysteine-tRNA synthetaseare upregulated