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The highest-evidence options are GLP-1 receptor agonists semaglutide and tirzepatide -- these have large phase 3 human RCT data showing 15-22% body weight reduction
What to track at each dose tier Record these metrics weekly throughout your escalation: Body weight: Same day, same time, same conditions (morning, fasted, after bathroom) Waist circumference: Most reliable non-scale metric for fat loss Appetite level: Rate 1-10 daily, average weekly Side effects: Type, severity, duration, timing relative to injection Energy level: Rate 1-10 daily, average weekly Injection volume and site: Document every injection for reference This data becomes invaluable at decision points
Tirzepatide tends to produce more weight loss but costs more
Consider adding a daily antihistamine (like cetirizine) after consulting your doctor, as this can reduce itching from inflammatory pathways without interfering with semaglutide efficacy
Dupilumab for neurodermatitis: indication of an added benefit in adults, Press releases
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