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The optimal stability range for these formulations is pH 6.07.5 , with maximum methionine oxidation rates for the parent protein occurring at pH 6-7

Discussion From a clinical point of view, the results obtained will help establish whether the oral administration of vitamin B12 is as effective as intramuscular treatment in the normalisation of serum vitamin B12 concentrations in patients 65 years of age with a deficiency

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While the liver produces some choline, it's not always in sufficient amounts

After the deficiency is fixed, injections might be needed only once a month

As such, low B12 levels can cause low oxygen levels and nerve problems