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It begins below the obesity-trial floor because appetite and gastrointestinal effects need time to adapt before escalation. At 5 mg, both GIP and GLP-1 are clinically active

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Neuropsychopharmacology, 31 (7), 1545-1549

Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk