Monitoring typically includes weight checks every 2 to 4 weeks, assessment of hunger and satiety cues, and evaluation of adherence to eating and movement goals
Tirzepatide (Zepbound, Mounjaro) : discontinue at least 1 month before pregnancy per Canadian labeling
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While injectable semaglutide resulted in average weight loss (at 40 weeks) of almost 7% of body weight, those taking tirzepatide had lost 13% at the same timepoints
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In a 52 week Phase 2 trial, overweight/obese individuals without diabetes lost 13.7% of their body weight (placebo subtracted) after receiving maridebart cafraglutide (420 mg once monthly), and overweight/obese individuals with diabetes lost 10.6% of their body weight and saw a decrease in HbA 1c of ~17 mmol/mol (1.5%, placebo subtracted) after receiving maridebart cafraglutide at the same dose (Table 2) [55]