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In preclinical studies, 5-Amino-1MQ provides a powerful tool to dissect the cellular and molecular consequences of NNMT inhibition

Compound over time

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Finally, our structural model of the 2:2 c-MET:NK1 complex shows that distinct from the way that HGF activates c-MET, the NK1 dimer recruits two c-METs in a symmetric manner

Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer