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BRIN-BD11 cells were used throughout this study for their well characterised responses to multiple stimuli, cell culture based convenience and their established intact response to GLP-1R activation both in terms of cAMP and resulting stimulated insulin secretion 36, 37

Int J Reprod Biomed 19:493504

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This study population was divided into two cohorts: (1) semaglutide cohort 25,686 patients prescribed semaglutide, and (2) Non-GLP-1RA anti-diabetes medication cohort 573,117 patients prescribed non-GLP-1RA anti-diabetes medications

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Lele Wang, [email protected] These authors have contributed equally to this work and share first authorship These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers