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DPP-4 can also have signaling functions via interactions with the extracellular matrix (90), and it was therefore speculated that the DPP-4 inhibitor might have improved insulin sensitivity by interfering with this process in some way rather than by blocking the enzymatic activity per se (79, 89)

How Glutathione whitening Glutathione's skin whitening mechanism is mainly based on inhibiting the enzyme tyrosinase, the enzyme responsible for melanin synthesis in the body

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B12 deficiency Vitamin B12 is water-soluble and is naturally found in some foods, such as meat, fish, and dairy products

Diabetes Care 45(7):15741583 Romero-Corral A, Somers VK, Sierra-Johnson J et al (2010) Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality

Vila Petroff MG, Egan JM, Wang X, Sollott SJ: Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes